Polygenic risk reports
Your DNA. Thirteen psychiatric traits. One clear report.
Upload raw data from AncestryDNA or 23andMe and get a free analysis of ADHD and Anxiety in about a minute. Unlock all 13 traits for $29 $49 — launch pricing, save $20.
Example finding from a real report
Somewhat below average for European-ancestry reference population. Based on 27 independent loci from PGC ADHD 2022.
What is Genetic Psychiatric Insights?
Genetic Psychiatric Insights computes polygenic risk scores (PRS) for 13 psychiatric traits from your AncestryDNA or 23andMe raw data file. ADHD and Anxiety are free; $29 one-time unlocks the remaining 11.
Every trait score is built from Psychiatric Genomics Consortium (PGC) GWAS summary statistics — the largest genome-wide association studies published for each condition. Your report lists percentile rank relative to a European-ancestry reference population, the top contributing variants, and an explicit citation to the source study. No proprietary algorithm, no black-box combinatorial scoring.
The 13 traits: ADHD, Anxiety, Major Depressive Disorder, Schizophrenia, Bipolar Disorder, PTSD, Autism Spectrum Disorder, OCD, Tourette Syndrome, Anorexia Nervosa, Substance Use Disorder, Borderline Personality Disorder, and a cross-disorder psychiatric score.
How it works
Upload
Drop in your raw DNA .txt file from AncestryDNA or 23andMe. No account, no credit card. Format is auto-detected.
Free preview runs
ADHD and Anxiety analyses complete in about a minute, with percentiles, top contributing SNPs, and PGC citations.
Unlock all 13 — $29 $49
One Stripe payment unlocks the full set. Same methodology, same citations, same honesty. Your raw DNA is deleted once the full analysis completes.
What's in every report
Every trait finding is plain-English first, clinical on demand, and explicitly honest about what polygenic risk scores can and cannot predict.
Each trait opens with a percentile (how your score compares to the reference population) and a one-sentence interpretation. Below that, the report surfaces the top 15–25 variants that contributed most to your score, with effect sizes, and links to the primary GWAS publication. Inflated scores from linkage disequilibrium are flagged directly in the finding instead of hidden behind a methodology footnote.
Every trait also carries a “what this does not tell you” section that names specific limitations — ancestry of the training cohort, effect-size uncertainty, and the gap between genetic liability and clinical diagnosis.
How this compares to other DTC raw-data tools
No other direct-to-consumer upload-based tool focuses on psychiatric polygenic risk specifically. Most bury mental-health traits in a broader catalog of hundreds of reports — or do not accept uploads at all.
| Genetic Psychiatric Insights | SelfDecode | Genomelink | 23andMe (native) | |
|---|---|---|---|---|
| Focus | 13 psychiatric traits only | 1,250+ reports across all domains | 290+ traits (broad lifestyle mix) | Included in a consumer kit |
| Price | $29 one-time (launch, was $49) | $119.88/yr + bundles $418–$894 | $29 one-time or $14/mo | $199+ for the DNA kit itself |
| Accepts AncestryDNA / 23andMe raw data | ✓ Both | ✓ Both | ✓ Both | ✗ Own kit only |
| PGC GWAS source cited per trait | ✓ With DOI | Proprietary weighting | Proprietary weighting | Not disclosed |
| Free preview | ✓ ADHD + Anxiety, no signup | ✓ Upload preview | ✓ 100 free traits | ✗ Must buy kit |
Nebula Genomics, which offered a similar upload-based model, shut down its consumer service on Feb 5, 2025. Prices and feature sets above reflect public information as of April 2026 and are subject to change.
What polygenic risk scores can and can't do
A polygenic risk score is a population-level statistic, not a personal diagnosis. It tells you how your common-variant profile compares to a reference cohort — nothing about how or whether a trait will manifest in your life.
PRS accuracy varies sharply by trait. Bipolar disorder and schizophrenia have relatively strong GWAS foundations (AUC roughly 0.68–0.72 in independent samples); ADHD and depression sit lower. Most published PRS models were trained on European-ancestry cohorts and transport poorly to other populations — a limitation this report surfaces directly rather than hiding.
A high PRS percentile does not mean you have the condition, and a low percentile does not rule it out. This report is a research and educational tool. It is not a medical test, not a diagnosis, and not a substitute for evaluation by a qualified clinician.
Frequently asked questions
What file do I upload?
Your raw DNA file from AncestryDNA or 23andMe — a .txt export,
typically named raw_dna.txt or genome_FullName.txt.
Format is auto-detected; no account or credit card is needed for the free preview.
What does the free preview include?
Full polygenic risk analyses for ADHD and Anxiety Disorders, with percentiles relative to a European-ancestry reference population, top contributing variants, and citations to the source PGC GWAS. Results in about a minute.
What does the $29 full report include?
Polygenic risk scores for all 13 traits: ADHD, Anxiety, Depression, Schizophrenia, Bipolar, PTSD, Autism, OCD, Tourette Syndrome, Anorexia, Substance Use Disorder, Borderline Personality Disorder, and a cross-disorder psychiatric score. Same depth of citations and limitations disclosure as the free preview. One-time payment at launch pricing (was $49).
Is this a medical or diagnostic test?
No. This is a research and educational tool based on published GWAS summary statistics. Polygenic risk scores describe populations, not individuals, and should never be used to change treatment without a qualified clinician.
What happens to my DNA file?
Your raw DNA file is deleted as soon as the full analysis completes. Reports are retained up to 30 days so the tokenized report URL you receive stays usable. Nothing is shared with third parties.